Fluorine-19 NMR imaging of glucose metabolism

✍ Scribed by Tsutomu Nakada; Ingrid L. Kwee; Peter J. Card; Nicholas A. Matwiyoff; Beatrice V. Griffey; Richard H. Griffey

• Book ID: 102528588
• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 413 KB
• Volume: 6
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910060309

✦ Synopsis

Metabolic imaging reflecting glucose metabolism in the glycolytic and aldose reductase sorbitol (ARS) pathways was performed noninvasively in rat using fluorinated glucose analogs, 2-fluoro-2-deoxy-D-glucose (2-FDG) or 3-fluoro-3-deoxy-D-glucose (3-FDG), and fluorine-19 (19F) nuclear magnetic resonance (NMR) imaging. 19F images of 2-FDG-6-phosphate, a main metabolite of 2-FDG in the glycolytic pathway, showed high glucose utilization in the brain, spinal cord, and heart. Images of 3-fluoro-3-deoxy-D-sorbitol (3-FDSL), a main metabolite of 3-FDG in the ARS pathway, demonstrated the heterogeneous nature of the spatial distribution of aldose reductase activities, being highest in the brain and lens. The extremely low toxicity of 3-FDG indicates promise for clinical application of 3-FDG NMR imaging.