New approach to metabolism of 5′-deoxy-5-fluorouridine in humans with fluorine-19 NMR

✍ Scribed by Marie-Catherine Malet-Martino; Robert Martino; André Lopez; Jean-Pierre Béteille; Maryse Bon; Jean Bernadou; Jean-Pierre Armand

• Book ID: 104758010
• Publisher: Springer
• Year: 1984
• Tongue: English
• Weight: 466 KB
• Volume: 13
• Category: Article
• ISSN: 0344-5704
• DOI: 10.1007/bf00401443

✦ Synopsis

The metabolism of 5'-deoxy-5-fluorouridine (5'dFUrd), an antitumor fluoropyrimidine, has been investigated in human biofluids (blood, plasma, urine) using a new method: fluorine-19 NMR spectrometry. This method allows direct study of the biological sample and simultaneous identification of all the fluorinated metabolites. In the blood of a patient treated with 5'dFUrd during a 6-h continuous perfusion, we observed unmetabolized 5'dFUrd, 5-fluorouracil, 5,6-dihydrofluorouracil, and another metabolite which has not previously been reported alpha-fluoro-beta-alanine. The two major metabolites in urine are unmetabolized 5'dFUrd and alpha-fluoro-beta-alanine.