Fluorine-18-labelled NCQ 115, a selective dopamine D-2 receptor ligand. Preparation and positron emission tomography
✍ Scribed by Halldin, Christer; Högberg, Thomas; Farde, Lars
- Book ID
- 123255773
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 466 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0969-8051
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Tropapride, (exo)-2,3-dimethoxy-N-[8-(phenylmethyl)-8- azabicyclo[3.2.1]oct-3-yl]benzamide hydrochloride, has been labeled with fluorine-18 at the 2- and 4-positions of its benzylic group. Two synthetic pathways were investigated: the first one required the alkylation of the norbenzyl precursor with
## Abstract Iodobenzamide (IMB) labeled with either [^11^C] or [^125^I] was studied in mice and baboons. Pharmacological studies demonstrated an in vivo binding profile compatible with D~2~ dopamine receptors. Mouse biodistribution studies with both [^11^C]IMB and [^125^I]IMB showed a similar brain