Fluorinated analogs and tritiated enantiomers of inositol (1,3,4)-trisphosphate
โ Scribed by Boehm Marcus F; Prestwich Glenn D
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- French
- Weight
- 256 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Both natural D-and L-enantiomers of myo-lns(l,4,5)P3 were synthesized with specific activities 14-16 Ci/mmol. A suitable inositol derivative was resolved as the diastereomeric camphanate esters, and the chiral inositol derivatives were oxidized to the protected inosose. Reduction of each chirai keto
sn-myo-Inositol-1,4,5\_trisphophate (Ins(1,4,5)PJ) and its enantiomers are prepared by synthesis of suitably protected myo-inositols, separation of enantiomers via the formation of D-mannose diastereomeric derivatives and selective phosphorylations. sn~m~-Inositol-~,4,5-trisphosphate lns(1,4,5)?, (-