The dtfluoromethyl carboxyk acid s-(+)-g was synthesized to assign the absolute configuration of diastewomere a and Ih, and the completion of the synthesis of ~difluoromethyl-mtyrosines lab is reported.
Fluorinated amino acids Part 2: Synthesis of diastereomeric N-acyloxazolidinone precursors
✍ Scribed by Jeffrey S. Sabol; Ian A. McDonald
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- French
- Weight
- 212 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
Evans' chiral auxiliary is used to resolve 3difluoromethyl-3-(3benzyloxyphenyl)propionic acid ca), which provides key building blocks for the synthesis of chiral &substituted m-tyrosine derivatives.
📜 SIMILAR VOLUMES
## Abstract N‐Propanoyl‐, N‐butanoyl‐, N‐pentanoyl‐, N‐hexanoyl‐, N‐heptanoyl‐ and N‐crotonoyl‐[1‐^14^C]‐D‐glucosamine were synthesized from [1‐^14^C]‐D‐glucosamine and their respective carbonic acid anhydrides as precursors for the biosynthesis of the corresponding N‐acyl neuraminic acids. The N‐a
Efficient syntheses of all diastereomers of methyl 2,5-anhydro-3-deoxy-hexonate from mannono-or gulono-lactones provide precursors for C-nucleosides of 2-deoxyribose and for THF-templated gand d-amino acids.