✦ LIBER ✦

Synthesis of N-Acyl-2-amino-2-deoxy-[1-14C]-glucoses as precursors for the biosynthesis of novel N-acylneuraminic acids

✍ Scribed by Holger Kayser; Reinhard Zeitler; Berthold Hoppe; Werner Reutter

Publisher: John Wiley and Sons
Year: 1992
Tongue: French
Weight: 219 KB
Volume: 31
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580310910

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✦ Synopsis

Abstract

N‐Propanoyl‐, N‐butanoyl‐, N‐pentanoyl‐, N‐hexanoyl‐, N‐heptanoyl‐ and N‐crotonoyl‐[1‐^14^C]‐D‐glucosamine were synthesized from [1‐^14^C]‐D‐glucosamine and their respective carbonic acid anhydrides as precursors for the biosynthesis of the corresponding N‐acyl neuraminic acids. The N‐acyl‐glucosamines are phosphorylated to their respective phosphate by N‐acetyl‐glucosamine kinase in a rat liver homogenate. These precursors may become valuable tools to investigate the biological role of the N‐acyl side chain of N‐acyl‐glucosamines and N‐acyl neuraminic acids which are components of glycoconjugates.

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