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Fluorescence resonance energy transfer as a structural tool for nucleic acids

โœ Scribed by David MJ Lilley; Timothy J Wilson


Book ID
104414457
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
394 KB
Volume
4
Category
Article
ISSN
1367-5931

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โœฆ Synopsis


Fluorescence resonance energy transfer is a spectroscopic method that provides distance information on macromolecules in solution in the range 20-80 A. It is particularly suited to the analysis of the global structure of nucleic acids because the long-range distance information provides constraints when modelling these important structures. The application of fluorescence resonance energy transfer to nucleic acid structure has seen a resurgence of interest in the past decade, which continues to increase. An especially exciting development is the recent extension to single-molecule studies.


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