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Fluorescence determination of metoprolol in human plasma by trilinear decomposition-based calibration techniques

✍ Scribed by Yan Zhang; Hai-Long Wu; A-Lin Xia; Shao-Hua Zhu; Qing-Juan Han; Ru-Qin Yu


Book ID
105890357
Publisher
Springer
Year
2006
Tongue
English
Weight
248 KB
Volume
386
Category
Article
ISSN
1618-2650

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Determination of metoprolol in human pla
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## Abstract A simple, specific and sensitive HPLC method has been developed for the determination of metoprolol in human plasma and urine. Separation of metoprolol and atenolol (internal standard) was achieved on an Ace C~18~ column (5 μm, 250 mmΓ—4.6 mm id) using fluorescence detection with Ξ»~ex~=2