𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Fluid dynamics of cell cytokinesis — Numerical analysis of intracellular flow during cell division

✍ Scribed by F. Zheng; C. Basciano; J. Li; A.V. Kuznetsov


Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
809 KB
Volume
34
Category
Article
ISSN
0735-1933

No coin nor oath required. For personal study only.

✦ Synopsis


Intracellular flow of cytoplasmic fluid during cell cytokinesis is investigated. The intercellular bridge connecting two daughter cells is modeled as a cylindrical microchannel whose squeezing causes cytoplasmic flow inside the bridge itself and into the daughter cells. An equation from recent experimental measurements by Zhang and Robinson [W. Zhang, D.N. Robinson, Balance of actively generated contractile and resistive forces controls cytokinesis dynamics, Proceedings of the National Academy of Sciences of the United States of America 102 (2005) 7186-7191.] that governs the dynamics of bridge thinning is implemented in this model. The purpose of this research is to compute intracellular flow induced by the bridge thinning process. Two different types of boundary conditions are compared at the membrane-cytoplasm interface; these are a no-slip condition and a no tangential stress condition. Pressure and flow velocity distributions in the daughter cells and the force exerted by this flow on the daughter cell nucleus are computed. It is established that the pressure difference between the daughter cell and the intercellular bridge increases as time progresses. It is also observed that a region of stagnation develops on the downstream side of the nucleus as the bridge thins.


📜 SIMILAR VOLUMES


Flow cytometric study of changes in the
✍ Gopal Pande; N. Anil Kumar; P. S. Manogaran 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 770 KB

We measured the intracellular levels of free cytoplasmic calcium in Werent phases of the cell cycle in viable rat fibroblasts, using two parameter flow cytometric analysis with Hoechst 33342 as the DNA specific dye and Fluo-3 as the calcium sensitive dye. We studied changes in calcium levels during

Analysis of cell cycle activity and popu
✍ Wandee Yanpaisan; Nicholas J. C. King; Pauline M. Doran 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 217 KB 👁 2 views

Flow cytometry was used to measure cell cycle parameters in Solanum aviculare plant cell suspensions. Methods for bromodeoxyuridine (BrdU) labeling of plant nuclei were developed so that cell cycle times and the proportion of cells participating in growth could be determined as a function of culture

Flow cytometric analysis of cell-surface
✍ Rogelio Paredes-Aguilera; Lina Romero-Guzman; Norma Lopez-Santiago; Lenny Burban 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 40 KB 👁 2 views

## Abstract To evaluate the usefulness of flow cytometric detection of intracellular antigens (Ags) in establishing proper lineage affiliation and its contribution to the diagnosis of acute leukemia, we studied 100 consecutive patients in whom acute leukemia was diagnosed between January 1997 and J