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Fluctuations in the polymerization of sickle hemoglobin

โœ Scribed by Szabo, Attila


Book ID
122733330
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
353 KB
Volume
199
Category
Article
ISSN
0022-2836

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Crowding and the polymerization of sickl
โœ Frank A. Ferrone; Maria A. Rotter ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 135 KB

## Abstract Under physiological conditions, sickle hemoglobin, a natural mutant of human hemoglobin A with a surface hydrophobic valine in place of a negatively charged glutamic acid, polymerizes at high volume occupancy. Equilibrium solubility of sickle hemoglobin entails activity coefficients tha