Fluctuations in plasma levodopa and motor responses with liquid and tablet levodopa/carbidopa

✍ Scribed by L. Verhagen Metman; J. Hoff; M. M. Mouradian; Dr. T. N. Chase

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 284 KB
• Volume: 9
• Category: Article
• ISSN: 0885-3185
• DOI: 10.1002/mds.870090416

✦ Synopsis

Abstract

To evaluate the ability of orally administered liquid levodopa/carbidopa (LD/CD) to stabilize plasma levodopa levels and reduce motor reponse fluctuations in Parkinson's disease, five patients received LD/CD hourly, as standard tablets or as an aqueous solution on two separate days in a double‐blind, placebo‐controlled, cross‐over design. Except for a slightly earlier peak plasma levodopa level, no significant advantage of the liquid formulation over tablet therapy was found. However, liquid LD/CD could be helpful in quickly resolving “off” states and by facilitating small dose adjustments that are not possible with tablets.