Duodenal delivery of levodopa for on-off
โ
Dr Roger Kurlan; Allen J. Rubin; Charlyne Miller; Leonor Rivera-Calimlim; Allan
๐
Article
๐
1986
๐
John Wiley and Sons
๐
English
โ 418 KB
๐ 1 views
The pathogenesis of on-off motor fluctuations in parkinsonism remains incompletely understood, but slowed or erratic gastric emptying of orally administered levodopa may be involved. In 3 patients with resistant on-off fluctuations, direct duodenal continuous infusion of levodopa via a nasoduodenal