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FLT3 is fused to ETV6 in a myeloproliferative disorder with hypereosinophilia and a t(12;13)(p13;q12) translocation

✍ Scribed by Vu, H A; Xinh, P T; Masuda, M; Motoji, T; Toyoda, A; Sakaki, Y; Tokunaga, K; Sato, Y

Book ID: 110056784
Publisher: Nature Publishing Group
Year: 2006
Tongue: English
Weight: 218 KB
Volume: 20
Category: Article
ISSN: 0887-6924
DOI: 10.1038/sj.leu.2404266

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## Abstract The SRC family of kinases is rarely mutated in primary human tumors. We report the identification of a SRC‐like tyrosine kinase gene, __FRK__ (Fyn‐related kinase), fused with __ETV6__ in a patient with acute myelogenous leukemia carrying t(6;12)(q21;p13). Both reciprocal fusion transcri