Flow-dependent platelet behaviour in blood—material interactions

✍ Scribed by G. P. A. Michanetzis; Y. F. Missirlis

• Publisher: Springer
• Year: 1996
• Tongue: English
• Weight: 383 KB
• Volume: 7
• Category: Article
• ISSN: 0957-4530
• DOI: 10.1007/bf00121186

✦ Synopsis

Platelet activation and adhesion are important parameters characterizing blood compatibility of biomaterials. A platelet transport theory based on convection diffusion, which describes the influence of wall shear rate, platelet concentration, axial position, hematocrit and red cell size, was originally proposed by Turitto and Baumgartner and later expanded by Aarts. This theory was applied in an in vitro perfusion system for three different materialswithwallshearratesbetweenl00s 1and4300s ~inordertocovertheregionsof diffusion controlled, reaction controlled and intermediate platelet adherence. Platelet diffusivity and platelet vessel wall surface reactivity were determined for these cases and the constants m and n were calculated using the relation between platelet diffusivity and shear rate as expressed by the following power law function: Dw =m*yw.n