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Flow cytometric analysis of T and Tn epitopes on chronic lymphocytic leukemia cells

✍ Scribed by Aller, Cynthia Timlick; Kucuk, Omer; Springer, Georg F.; Gilman-Sachs, Alice

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
968 KB
Volume
52
Category
Article
ISSN
0361-8609

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✦ Synopsis

lmmunophenotyping of peripheral blood lymphocytes from six patients with B-cell chronic lymphocytic leukemia (6-CLL) and five normal volunteers was done and their T and Tn epitopes analyzed using specific monoclonal antibodies and flow cytometry. Lymphocytes from all patients showed strong Tn expression as compared to normal control lymphocytes. By contrast, T antigen was not expressed. The Tn expression may be a useful diagnostic and prognostic marker for B-CLL.

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Automated classification of patients with chronic lymphocytic leukemia and immunocytoma from flow cytometric three-color immunophenotypes
✍ G.K. Valet; H.-G. HΓΆffkes πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 240 KB

The goal of this study was the discrimination between chronic lymphocytic leukemia (B-CLL), clinically more aggressive lymphoplasmocytoid immunocytoma (LP-IC) and other low-grade non-Hodgkin's lymphomas (NHL) of the B-cell type by automated analysis of flow cytometric immunophenotypes CD45/14/20, CD