Flow cytometric analysis of lymphocyte subpopulations in infants with congenital heart disease

✍ Scribed by Dr. Herbert B. Slade; Jay H. Greenwood; Robert H. Beekman III; Jerry L. Hudson; Savita Pahwa; Stanley A. Schwartz

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 601 KB
• Volume: 3
• Category: Article
• ISSN: 0887-8013
• DOI: 10.1002/jcla.1860030105

✦ Synopsis

Premortem diagnosis of the DiGeorge fants undergoing diagnostic cardiac cathsyndrome and its partial variants relies on eterization. Striking differences were seen the demonstration of a primary defect in between patients and adult controls in cell-mediated immunity, generally in the means percentages and numbers of most setting of an infant with congenital heart lymphocyte subsets analyzed. Few differdisease, hypocalcemia, absence of a ences were found in comparing the patient thymic shadow, and typical dysmorphic data to values for age-matched control infeatures. Although T-cell enumeration is fants without heart disease. The data are considered a vital part of the diagnostic discussed with reference to published valevaluation, no studies to date have ad-ues for patients with partial DiGeorge syndressed the issue of appropriate reference drome. It is concluded that lymphocyte data in infants with congenital heart dis-phenotype analysis in the diagnostic evalease. We therefore undertook a prospec-uation of patients with suspected Ditive descriptive study of lymphocyte George syndrome must utilize appropriate phenotype analysis in 27 nontransfused in-