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Screening and biochemical analysis of GATA4 sequence variations identified in patients with congenital heart disease

โœ Scribed by Marie K. Schluterman; Amanda E. Krysiak; Irfan S. Kathiriya; Nicola Abate; Manisha Chandalia; Srivastava Deepak; Vidu Garg

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
192 KB
Volume
143A
Category
Article
ISSN
1552-4825

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GATA4 haploinsufficiency in patients with interstitial deletion of chromosome region 8p23.1 and congenital heart disease
โœ Pehlivan, Tugce; Pober, Barbara R.; Brueckner, Martina; Garrett, Stacey; Slaugh, ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 23 KB ๐Ÿ‘ 2 views

Previous studies have shown that patients with deletion of distal human chromosome arm 8p may have congenital heart disease and other physical anomalies. The gene encoding GATA-4, a zinc finger transcription factor implicated in cardiac gene expression and development, localizes to chromosome region