✦ LIBER ✦

Flexibility of active-site gorge aromatic residues and non-gorge aromatic residues in acetylcholinesterase

✍ Scribed by Pavan K. GhattyVenkataKrishna, Neelima Chavali, Edward C. Uberbacher

Book ID: 120948634
Publisher: Versita
Year: 2013
Tongue: English
Weight: 263 KB
Volume: 67
Category: Article
ISSN: 0366-6352
DOI: 10.2478/s11696-013-0354-4

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The presence of an unusually large number of aromatic residues in the active site gorge of acetylcholinesterase is a subject of great interest. Flexibility of these residues has been suspected to be a key player in controlling the ligand traversal in the gorge. This raises the question of whether the over-representation of aromatic residues in the gorge implies higher-than-normal flexibility of these residues. The current study suggests that it does not. Large changes in the hydrophobic cross-sectional area due to dihedral oscillations are probably the reason of their presence in the gorge.

📜 SIMILAR VOLUMES

(37) Ligand-induced conformational chang

(37) Ligand-induced conformational changes in residues flanking the active site gorge of acetylcholinesterase

✍ Leo Pezzementi; Jianxin Shi; David A. Johnson; Zoran Radic; Aileen Boyd; Palmer 📂 Article 📅 2005 🏛 Elsevier Science 🌐 English ⚖ 92 KB

Binding sites of acetylcholine in the ar

Binding sites of acetylcholine in the aromatic gorge leading to the active site of acetylcholinesterase

✍ Alberte Pullman 📂 Article 📅 1995 🏛 Springer ⚖ 746 KB

Active-site gorge and buried water molec

Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica

✍ Gertraud Koellner; Gitay Kryger; Charles B. Millard; Israel Silman; Joel L. Suss 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 1000 KB

Roles of Active Site Aromatic Residues i

Roles of Active Site Aromatic Residues in Catalysis by Ketosteroid Isomerase from Pseudomonas putida Biotype B †

✍ Kim, Do-Hyung; Nam, Gyu Hyun; Jang, Do Soo; Choi, Gildon; Joo, Soyoung; Kim, Jeo 📂 Article 📅 1999 🏛 American Chemical Society 🌐 English ⚖ 448 KB

Does “Butyrylization” of Acetylcholinest

Does “Butyrylization” of Acetylcholinesterase through Substitution of the Six Divergent Aromatic Amino Acids in the Active Center Gorge Generate an Enzyme Mimic of Butyrylcholinesterase? †

✍ Kaplan, Dana; Ordentlich, Arie; Barak, Dov; Ariel, Naomi; Kronman, Chanoch; Vela 📂 Article 📅 2001 🏛 American Chemical Society 🌐 English ⚖ 166 KB

Rapid binding of a cationic active site

Rapid binding of a cationic active site inhibitor to wild type and mutant mouse acetylcholinesterase: Brownian dynamics simulation including diffusion in the active site gorge

✍ Sylvia Tara; Adrian H. Elcock; Paul D. Kirchhoff; James M. Briggs; Zoran Radic; 📂 Article 📅 1998 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 133 KB 👁 2 views

It is known that anionic surface residues play a role in the long-range electrostatic attraction between acetylcholinesterase and cationic ligands. In our current investigation, we show that anionic residues also play an important role in the behavior of the ligand within the active site gorge of ac