A novel formulation process via co-spray drying ibuprofen (IBU) with mesoporous SBA-15 submicron particles exhibited excellence in production of stable amorphous IBU with significantly enhanced dissolution rate. With drug loading of IBU/SBA-15 ratio being 50:50 (w/w) or below, most drug molecules we
✦ LIBER ✦
Flavonoid microparticles by spray-drying: Influence of enhancers of the dissolution rate on properties and stability
✍ Scribed by F. Sansone; P. Picerno; T. Mencherini; F. Villecco; A.M. D’Ursi; R.P. Aquino; M.R. Lauro
- Book ID
- 108171701
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 1023 KB
- Volume
- 103
- Category
- Article
- ISSN
- 0260-8774
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During spray drying, emphasis is placed on process optimisation to generate favourable particle morphological and flow properties. The effect of the initial feed solution composition on the drug release from the prepared microparticles (MPs) is rarely considered. We investigated the effects of solve