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FK506: A novel immunosuppressant with potential antibiotic interactions

โœ Scribed by Victor D. Bowers; John T. Sinnott IV; Rocio Flores

Book ID
119159728
Publisher
Elsevier Science
Year
1993
Weight
296 KB
Volume
12
Category
Article
ISSN
0278-2316

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The distribution kinetics of a novel potent immunosuppressant, FK-506 (FK) has been studied in comparison with cyclosporin A (CyA) both in vivo and in vitro using blood specimens. The infusion studies on FK, 5.0mg kg-1 through the portal and femoral veins showed that the mean hepatic extraction rati