Five-day infusion of fluorodeoxyuridine with high-dose oral leucovorin: a phase I study
β Scribed by Everett E. Vokes; James W. Raschko; Nicholas J. Vogelzang; Elizabeth E. Warfield; Mark J. Ratain; James H. Doroshow; Richard L. Schilsky
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 583 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0344-5704
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π SIMILAR VOLUMES
Background. In a previous Phase I1 trial, the authors showed that a weekly continuous infusion of 5-fluorouracil (5-FU) at a dose of 3.5 g/mz for 48 hours is an active treatment for advanced colorectal cancer. The overall response rate was 38.5%, and the median survival was 12 months. These data wer
Two consecutive Phase I trials of continuous infusion 5-fluorouracil (5-FU) or floxuridine (5-FUdR) admixed with leucovorin (LCV) were performed and involved 19 and 24 patients, respectively. The studies were carried out to identify the optimal dose rate of delivery for the two admixtures (5-FU + LC