Continuous-infusion fluorodeoxyuridine with leucovorin and high-dose interferon: a phase II study in metastatic renal-cell cancer
β Scribed by Walter M. Stadler; Nicholas J. Vogelzang; Everett E. Vokes; Jane Charette; Greg Whitman
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 395 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0344-5704
No coin nor oath required. For personal study only.
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Background. In a previous Phase I1 trial, the authors showed that a weekly continuous infusion of 5-fluorouracil (5-FU) at a dose of 3.5 g/mz for 48 hours is an active treatment for advanced colorectal cancer. The overall response rate was 38.5%, and the median survival was 12 months. These data wer
## RESULTS. Fifty-five patients were enrolled in the trial and 52 were evaluable for ogy, The University of Texas M. D. Anderson response. All patients experienced fever and flu-like symptoms. Grade 3 or 4 nonhe-Cancer Center, Houston, Texas. matologic toxic effects included hypertension (48%), d