Synthesis and evaluation of tripeptidyl
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Shu-Hui Chen; Jason Lamar; Frantz Victor; Nancy Snyder; Robert Johnson; Beverly
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Article
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2003
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Elsevier Science
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English
β 242 KB
We describe herein the synthesis and biological evaluation of a series of tripeptidyl a-ketoamides as human rhinovirus (HRV) 3C protease inhibitors. The most potent inhibitor discussed in this manuscript, 4I, exhibited impressive enzyme inhibitory activity as well as antiviral activity against HRV-1