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Fisetin and rutin as 3C protease inhibitors of enterovirus A71

✍ Scribed by Ying-Ju Lin; Yi-Chih Chang; Nai-Wan Hsiao; Jing-Ling Hsieh; Ching-Ying Wang; Szu-Hao Kung; Fuu-Jen Tsai; Yu-Ching Lan; Cheng-Wen Lin


Book ID
113768902
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
453 KB
Volume
182
Category
Article
ISSN
0166-0934

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We describe herein the synthesis and biological evaluation of a series of tripeptidyl a-ketoamides as human rhinovirus (HRV) 3C protease inhibitors. The most potent inhibitor discussed in this manuscript, 4I, exhibited impressive enzyme inhibitory activity as well as antiviral activity against HRV-1