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First unequivocal synthesis of dissymmetrical trans N,N′-difunctionalized 1,4,8,11-tetraazacyclotetradecane

✍ Scribed by Christophe Bucher; Guy Royal; Jean-Michel Barbe; Roger Guilard

Book ID: 104260986
Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 190 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)00190-2

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✦ Synopsis

The first unequivocal synthesis of disymmetrical trans N,N'-difunctionalized tetraazamacrocycles in cyclam series is reported. This convenient four-step method can be used for the synthesis of various trans N,N'-difunctionalized tetraazamacrocycles bearing two different pendant donor arms.

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