We have examined maternal urine concentrations of beta core, free beta human chorionic gonadotrophin (hCG), and total oestriol in 373 control pregnancies and 43 pregnancies affected by aneuploidy (including 22 cases of Down's syndrome) in an attempt to see if any of the analytes have a value in Down
First trimester down syndrome screening: The impact of using total HCG instead of free HCG
โ Scribed by Mark Evans; David Krantz; Terrence Hallahan
- Book ID
- 113430344
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 61 KB
- Volume
- 193
- Category
- Article
- ISSN
- 1097-6868
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Human chorionic gonadotropin (hCG) free beta-subunit levels were determined in 709 control and 13 Down syndrome urine samples from the second trimester of pregnancy. Results were normalized to urine creatinine concentration and converted to multiples of the unaffected pregnancy medium (MOM). The con
Biochemical screening for Down syndrome (DS) is well established in the second trimester of pregnancy, but there is little information available on its value in the first trimester. This study describes our preliminary results with biochemical screening for DS in the first trimester of pregnancy in