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First-trimester biochemical markers for Down syndrome

✍ Scribed by Elena Casals; Carlos Aibar; Josep Maria Martínez; Antoni Borrell; Anna Soler; Julia Ojuel; Antonio Manuel Ballesta; Albert Fortuny

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
154 KB
Volume
19
Category
Article
ISSN
0197-3851

No coin nor oath required. For personal study only.

✦ Synopsis

The value of maternal serum pregnancy-associated protein A (PAPP-A), free and total human chorionic gonadotrophin (f hCG, hCG) and -fetoprotein (AFP) in screening for Down syndrome (DS) in early pregnancy has been assessed. To evaluate the different biochemical markers, 32 DS pregnancies and 267 controls were used for AFP, hCG and PAPP-A. A subgroup of those (17 DS and 136 controls) were used to evaluate f hCG. All analytes were determined in fresh serum samples. Our results give support to the feasibility of maternal serum levels of PAPP-A as the best biochemical marker for DS in the first trimester, and either hCG or f hCG as the second marker. No differences were found between hCG and f hCG distribution levels as expressed as MoMs in normal and DS pregnancies in this study.

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