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SCHWANGERSCHAFTSPROTEIN 1 (SP1) AS A MATERNAL SERUM MARKER FOR DOWN SYNDROME IN THE FIRST AND SECOND TRIMESTERS

✍ Scribed by Q.-P. QIN; M. CHRISTIANSEN; T. H. NGUYEN; S. SØRENSEN; S. O. LARSEN; B. NØRGAARD-PEDERSEN

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
237 KB
Volume
17
Category
Article
ISSN
0197-3851

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✦ Synopsis

The potential of the maternal serum concentration of schwangerschaftsprotein 1 (MSSP1) as a marker for Down syndrome (DS) pregnancies was evaluated in the fifth to the 20th gestational week using 156 DS pregnancies and 546 unaffected control pregnancies. In DS pregnancies, the median of the multiple of the median (MOM) of MSSP1 was 0•27 [95 per cent confidence interval (CI) 0•11-0•59] in weeks 5-9 (n=25) and 1•28 (CI 1•11-1•49) in weeks 14-20 (n=117), significantly different from controls (P<10 6 ). In weeks 10-12, the median MSSP1 MOM was 0•89 (CI 0•20-2•09) (n=14), not different from controls (P=0•42). Using MSSP1 alone as a marker for DS gave-in empirical receiver-operator-characteristics (ROC) analysis-a detection rate of about 44 per cent for a false-positive rate of about 5 per cent in weeks 5-9 (using MSSP1 MOMccut-off), whereas a sensitivity of about 20 per cent was found for a false-positive rate of 5 per cent in weeks 14-20 (using MSSP1 MOMdcut-off). In parameterized ROC analysis, the detection rates were 38 and 18 per cent for a false-positive rate of 5 per cent in weeks 5-9 and 14-20, respectively. 1997 by John Wiley & Sons, Ltd.

 : pregnancy-specific 1-glycoprotein; time-resolved

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