✦ LIBER ✦

First total synthesis of the antifungal antibiotic thiobutacin

✍ Scribed by Narayan Chakor; Sabrina Dallavalle; Loana Musso; Maddalena Moretti

Publisher: Elsevier Science
Year: 2008
Tongue: French
Weight: 157 KB
Volume: 49
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2008.06.036

No coin nor oath required. For personal study only.

✦ Synopsis

The first total synthesis of thiobutacin, a butanoic acid with antifungal activity recently isolated from the culture broth of a soil actinomycete, Lechevalieria aerocolonigenes strain VK-A9, is described. The five-step procedure involves readily available and cheap starting materials and can easily be transposed to the large scale. Fungal growth inhibition of thiobutacin is mediated by the pH of the growth medium. Maximum inhibitory activity was obtained between pH 6 and 7.

📜 SIMILAR VOLUMES

A Concise Total Synthesis of Antifungal

A Concise Total Synthesis of Antifungal Antibiotic (+)-Preussin.

✍ Naminita Gogoi; Joshodeep Boruwa; Nabin C. Barua 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 9 KB 👁 1 views

A Concise Total Synthesis of Antifungal

A Concise Total Synthesis of Antifungal Antibiotic (+)-Preussin

✍ Naminita Gogoi; Joshodeep Boruwa; Nabin C. Barua 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 96 KB 👁 1 views

First total synthesis of the antitumor a

First total synthesis of the antitumor antibiotic (±)-resorthiomycin

✍ Datta E. Ponde; S. Ramalingam; Mahesh L. Patil; Hanumant B. Borate; Vishnu H. De 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 104 KB

Structure and total synthesis of chrysca

Structure and total synthesis of chryscandin, a new antifungal antibiotic

✍ Michio Yamashita; Yoshio Kawai; Itsuo Uchida; Tadaaki Komori; Masanobu Kohsaka; 📂 Article 📅 1984 🏛 Elsevier Science 🌐 French ⚖ 209 KB

First Asymmetric Total Synthesis of Syne

First Asymmetric Total Synthesis of Synerazol (I), an Antifungal Antibiotic, and Determination of Its Absolute Stereochemistry.

✍ Yujiro Hayashi; Mitsuru Shoji; Takasuke Mukaiyama; Hiroaki Gotoh; Shinpei Yamagu 📂 Article 📅 2005 🏛 John Wiley and Sons ⚖ 11 KB 👁 1 views

The First Total Synthesis of a Tetracyli

The First Total Synthesis of a Tetracylic Antibiotic, (-)-Tetrodecamycin.

✍ Kuniaki Tatsuta; Yasuaki Suzuki; Akiho Furuyama; Hiroshi Ikegami 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 11 KB 👁 1 views