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First total synthesis of (+)-heteroplexisolide E

โœ Scribed by Noriki Kutsumura; Akito Kiriseko; Takao Saito


Book ID
113930800
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
406 KB
Volume
53
Category
Article
ISSN
0040-4039

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The first total synthesis of (ร€)-bitungolide E is described. The key steps include a Myers' alkylation, modified Evans' syn aldol-reaction, using Crimmins protocol, Sharpless asymmetric epoxidation and ringclosing metathesis reaction.