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First total synthesis of (+)-cassiol. A potent antiulcerogenic compound

✍ Scribed by Tadahiro Takemoto; Chikara Fukaya; Kazumasa Yokoyama


Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
118 KB
Volume
30
Category
Article
ISSN
0040-4039

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✦ Synopsis


The first total synthesis of (S)-(+)-Cassiol (2) is described. Cassioside (1). isolated from aqueous extract of Cinnamoni Cortex (Cinnamonurn cassia Blume; "Kannan Keihi" in .Japanese)la, showed serotoninlb induced antiulcerogenic activity


πŸ“œ SIMILAR VOLUMES


Detours en route to a total synthesis of
✍ Marı́a I. Colombo; Juan Zinczuk; Marı́a L. Bohn; Edmundo A. RΓΊveda πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 English βš– 279 KB

A synthesis of the antiulcerogenic compound (+)-cassiol 1b has been achieved in 43% yield starting with lactol (S)-2 and sulfone 26. This short and efficient synthesis features the one-pot Julia olefination reaction of the sodium anion of (S)-2 with 26, through the key intermediate (-)-9. This synth