Detours en route to a total synthesis of
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MarΔ±Μa I. Colombo; Juan Zinczuk; MarΔ±Μa L. Bohn; Edmundo A. RΓΊveda
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Article
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2003
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Elsevier Science
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English
β 279 KB
A synthesis of the antiulcerogenic compound (+)-cassiol 1b has been achieved in 43% yield starting with lactol (S)-2 and sulfone 26. This short and efficient synthesis features the one-pot Julia olefination reaction of the sodium anion of (S)-2 with 26, through the key intermediate (-)-9. This synth