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First Total Synthesis and Structural Reassignment of (−)-Aplysiallene

✍ Scribed by Wang, Jian; Pagenkopf, Brian L.


Book ID
125543375
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
93 KB
Volume
9
Category
Article
ISSN
1523-7060

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✍ Zhen-Hua Ma; Ni Song; Chun-Xia Li; Wei Zhang; Peng Wang; Ying-Xia Li 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 180 KB

## Abstract The total synthesis of a marine acyclic peptide tasiamide and three diastereomers was reported for the first time. The synthesis has led to a reassignment of the __N__^α^‐Me‐L‐Gln of tasiamide to be __N__^α^‐Me‐D‐Gln, which was supported by ^1^H NMR, ^13^C NMR, COSY, HMQC, HMBC, and opt