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First Total Synthesis and Structural Confirmation of Fluvirucinine A 2 via an Iterative Ring Expansion Strategy

✍ Scribed by Lee, Yong-Sil; Jung, Jong-Wha; Kim, Seok-Ho; Jung, Jae-Kyung; Paek, Seung-Mann; Kim, Nam-Jung; Chang, Dong-Jo; Lee, Jeeyeon; Suh, Young-Ger


Book ID
126778296
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
228 KB
Volume
12
Category
Article
ISSN
1523-7060

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An efficient strategy for the iterative
✍ Nobuyuki Hori; Hiroko Matsukura; Goh Matsuo; Tadashi Nakata πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 259 KB

A highly efficient strategy for the iterative synthesis of a trans-fused polytetrahydropyran ring system was developed. The new iterative method involves SmI2-induced reductive intramolecular cyclization of an aldehyde and a [~-alkoxy acrylate as the key step, producing a 2,3-trans-tetrahydropyran r