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First Total Syntheses and Spectral Data Corrections of 11-α-Methoxycurvularin and 11-β-Methoxycurvularin

✍ Scribed by Liang, Qiren; Sun, Yongquan; Yu, Binxun; She, Xuegong; Pan, Xinfu


Book ID
126459238
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
84 KB
Volume
72
Category
Article
ISSN
0022-3263

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Stereoselective Total Synthesis of (11β)
✍ Karuturi Rajesh; Vangaru Suresh; Jondoss Jon Paul Selvam; Dokuburra Chanti Babu; 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 German ⚖ 164 KB

## Abstract A simple and highly efficient stereoselective total synthesis of (11__β__)‐11‐methoxycurvularin (**5**), a polyketide natural product, was achieved. The synthesis commenced with a Cu‐mediated regioselective opening of (2__S__)‐2‐methyloxirane (**6**) and comprised a __Keck__ asymmetric