A series of S-lactone (1 and Z), oxetane (3) and azetidinone (4 and 5) analogs were prepared from the HMG CoA synthase inhibitor L-659.699 ((E,E)-ll-[3'R-~ydymethyl)-4'-oxo-2'R-oxetanyl]-3,5,7Rtrimethyl-2,4-undecadienoic acid1v2), which maintained the truns relationship of the ring side chains. The
✦ LIBER ✦
First synthesis of two naturally occurring oxetane lactones: clementein and clementein b
✍ Scribed by Francisco A. Macías; José María G. Molinillo; Guillermo M. Massanet
- Book ID
- 104203901
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- French
- Weight
- 695 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4020
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## Abstract Enantiomerically pure diphenic ester 3 was obtained by esterification of acyl chloride 2 with the glucose derivative 1 by kinetic resolution. Hydrolysis of the ester 3, acylation of the free OH groups at C‐4 and C‐6 of the diol 4 with acid 5 followed by irradiation led to the anomerical