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First round of a focused library of cholera toxin inhibitors

✍ Scribed by Črtomir Podlipnik; Ingrid Velter; Barbara La Ferla; Gilles Marcou; Laura Belvisi; Francesco Nicotra; Anna Bernardi

Book ID
108080465
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
453 KB
Volume
342
Category
Article
ISSN
0008-6215

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✍ Stefania De Luca; Saraj Ulhaq; Mark J. Dixon; Jonathan Essex; Mark Bradley 📂 Article 📅 2003 🏛 Elsevier Science 🌐 French ⚖ 164 KB

A focused library of inhibitors of the enzyme trypanothione reductase was prepared using solid-phase synthesis. The inhibitors were based on a previously identified, non-competitive, lead compound comprising of two Pmc (2,2,5,7,8-pentamethylchroman-6-sulfonyl) side-chain protected, N-capped arginine