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Synthesis and Biological Activity of a Focused Library of Mitogen-activated Protein Kinase Phosphatase Inhibitors

โœ Scribed by David M. Arnold; Caleb Foster; Donna M. Huryn; John S. Lazo; Paul A. Johnston; Peter Wipf

Book ID
111368384
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
212 KB
Volume
69
Category
Article
ISSN
1747-0277

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โœ Peter Wipf; Diana C. Aslan; Diane K. Luci; Eileen C. Southwick; John S. Lazo ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 470 KB ๐Ÿ‘ 2 views

Phosphorylation of serine, threonine, and tyrosine controls fundamental mammalian cell events and is achieved by kinases which, in turn, are in dynamic relationship with phosphatases. Few selective inhibitors of protein tyrosine and dual specificity phosphatases are readily available. Based on SAR s