The disposition of the narcotic antagonist/analgesic nalbuphine after i.v., oral, and rectal dosing was evaluated in rats and dogs. In both species nalbuphine had high systemic clearance and low oral bioavailability as a result of extensive first-pass metabolism. Administration to a closed 2 cm leng
First-pass metabolism of ethinyl estradiol in dogs and rats
β Scribed by S. Hirai; A. Hussain; M. Haddadin; R. B. Smith
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 496 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0022-3549
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The peroral (po) bioavailability of nifedipine is reported to range from about 45 to 58% in the rat; this compares favourably to human beings. The metabolism of nifedipine is similar in rats and humans (oxidation of the dihydropyridine ring), with the liver believed to be solely responsible for the
## Abstract The contribution of gastrointestinal tract (GIT), liver, and lung towards the firstβpass metabolism of acetaminophen was examined using 3βweekβold, 10βweekβold and 1βyearβold rats after administration of 30mgkg^β1^ doses by intraβarterial, intravenous, intraperitoneal, and oral routes.
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