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First experience with enzyme replacement therapy during pregnancy and lactation in Pompe disease

✍ Scribed by Juna M. de Vries; Jan-Dietert C. Brugma; Lale Özkan; Eric A.P. Steegers; Arnold J.J. Reuser; Pieter A. van Doorn; Ans T. van der Ploeg


Book ID
116989450
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
884 KB
Volume
104
Category
Article
ISSN
1096-7192

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Enzyme replacement therapy induces T-cel
✍ Miklos Banati; Zsolt Hosszu; Anita Trauninger; Laszlo Szereday; Zsolt Illes 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 330 KB

## Abstract ## Introduction: Enzyme replacement therapy (ERT) in ultra‐orphan Pompe disease generates anti‐rhGAA antibodies, which may interfere with efficacy. ## Methods: rhGAA‐specific T‐cell responses were examined at different time‐points in 6 Hungarian patients treated with rhGAA and compar