✍ Scribed by Diego J. Ramón; Miguel Yus
No coin nor oath required. For personal study only.
The reaction of dimethyl or diethylzinc with ketones in the presence of a stoichiometric amount of titanium tetraisopropoxide and a catalytic amount (20 tool %) of camphorsulfonamide derivatives as chiral ligands leads to the formation of the corresponding enantioenriched alcohols with enantiomeric ratios up to 94.5:5.5, the best results being obtained when pbenones are used as substrates independently of the zinc reagent.
📜 SIMILAR VOLUMES
The reaction of diethylzinc or dimethylzinc with prostereogenic ketones, in the presence of a stoichiometric amount of titanium tetraisopropoxide and a catalytic amount (20%) of camphorsulfonamide derivatives as chiral ligands leads to the formation of the corresponding enantioenriched tert-alcohols
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