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First asymmetric synthesis of (R)-desmethylsibutramine

✍ Scribed by Dhileepkumar Krishnamurthy; Zhengxu Han; Stephen A. Wald; Chris H. Senanayake

Book ID: 104250721
Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 64 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)00297-6

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✦ Synopsis

A catalytic enantioselective addition of iBuLi to aldimine 3 derived from methyl amine and 1-(4-chlorophenyl) cyclobutanecarboxaldehyde is used as the key step in the asymmetric synthesis of (R)-desmethylsibutramine, a single enantiomer version of a pharmacologically active metabolite of anti-obesity drug sibutramine (Meridia ® ).

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