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The first practical asymmetric synthesis of R and S-Warfarin

✍ Scribed by Andrea Robinson; Hui-Yin Li; John Feaster


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
239 KB
Volume
37
Category
Article
ISSN
0040-4039

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## Abstract 4‐Hydroxy‐3‐[3‐oxo‐1‐(3‐bromophenyl)butyl]‐2H‐1‐benzopyran‐2‐one (3β€² ‐bromowarfarin) was synthesized and resolved into its enantiomers by formation of the __d__‐10‐camphorsulfonate diastereoisomers, which were separated by liquid chromatography and hydrolyzed. The pure enantiomers were