First aromatic electrophilic iodination reaction on the solid-phase: Iodination of bioactive peptides

✍ Scribed by Gemma Arsequell; Gemma Espuña; Gregorio Valencia; José Barluenga; Raquel Pérez Carlón; JoséM. González

• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 251 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)01604-9

✦ Synopsis

Direct iodination of Tyr residues of peptides anchored on solid supports was accomplished, for the first time, by aromatic eleclrophilic attack of iodonium ions provided by the IPy2BF 4 reagent. Compatibility studies of the iodination with routine solid-phase synthesis protocols are reported.