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ChemInform Abstract: Control of the Iodination Reaction on Activated Aromatic Residues in Peptides.

✍ Scribed by Gemma Espuna; Gemma Arsequell; Gregorio Valencia; Jose Barluenga; Marta Perez; Jose M. Gonzalez

Publisher
John Wiley and Sons
Year
2000
Weight
31 KB
Volume
31
Category
Article
ISSN
0931-7597

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πŸ“œ SIMILAR VOLUMES

First aromatic electrophilic iodination
First aromatic electrophilic iodination reaction on the solid-phase: Iodination of bioactive peptides
✍ Gemma Arsequell; Gemma EspuΓ±a; Gregorio Valencia; JosΓ© Barluenga; Raquel PΓ©rez C πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 French βš– 251 KB

Direct iodination of Tyr residues of peptides anchored on solid supports was accomplished, for the first time, by aromatic eleclrophilic attack of iodonium ions provided by the IPy2BF 4 reagent. Compatibility studies of the iodination with routine solid-phase synthesis protocols are reported.