𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Finite dose pharmacokinetics of skin penetration

✍ Scribed by E. R. Cooper; B. Berner

Book ID
102404793
Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
235 KB
Volume
74
Category
Article
ISSN
0022-3549

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✦ Synopsis

A model for estimating in vivo skin permeability coefficients for finite doses is presented. The ratio of the maximum value of the excretion rate to the steady-state flux is a function of the thickness of the applied vehicle and the vehicle-skin partition coefficient. The decay rate of the excretion is a function of skin-vehicle parameters for large doses and, under certain conditions, can even reduce to the total excretory rate constant as the dose is decreased.

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