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Fine-needle aspiration biopsy of hepatic angiosarcoma: Report of a case with immunocytochemical findings

✍ Scribed by John W. Wong; Dr. Yvan C. Bedard

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 437 KB
Volume: 8
Category: Article
ISSN: 8755-1039
DOI: 10.1002/dc.2840080416

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✦ Synopsis

Abstract

Hepatic angiosarcoma (Kupffer cell sarcoma) is a very rare but ominous malignancy. We report a case diagnosed by fine‐needle aspiration biopsy (FNAB). The smear showed malignant spindle cells and a few rounded cells. The diagnosis was made on the cell block by the characteristic scaffolding arrangement of malignant cells along preexisting hepatocytes. This is the first report with immunocytochemical findings. The tumour cells stained positively for vimentin and negatively for keratin, factor VIII, Ulex europaeus agglutinin I (UEA‐1), carcinoembryonic antigen (CEA), alpha‐fetoprotein (AFP), and lysozyme. This case demonstrates the possibility of a definitive diagnosis by FNAB prior to death without inflicting serious complications.

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