Fine mapping of HLA class II monoclonal antibody specificities using transfected L cells
β Scribed by Daniel M. Altmann; Judith M. Heyes; Hitoshi Ikeda; Amanda M. Sadler; David Wilkinson; J. Alejandro Madrigal; Julia G. Bodmer; John Trowsdale
- Publisher
- Springer-Verlag
- Year
- 1990
- Tongue
- English
- Weight
- 394 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0093-7711
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Among the HLA-DR-specific monoclonal antibodies (mAbs) that have been characterized previously, there is a marked shortage of DR alpha chain-specific mAbs which stain unfixed cells. This may result from the high degree of sequence similarity between the alpha 1 domains of HLA-DR and H-2E leading to
## Abstract Complexes of major histocompatibility complex (MHC) class II molecules containing invariant chain (Ii)βderived peptides, known as class IIβassociated invariant chain peptides (CLIP), are expressed at high levels in presentationβdeficient mutant cells. Expression of these complexes in mu