Three dominantly inherited "pure" form of familial spastic paraplegia (FSP) genes have been genetically mapped to regions of chromosomes, yet no specific genes or mutations have been identified (FSPI ; chromosome 14q, FSP2; chromosome 2p and FSP3; chromosome 15q). We studied a "pure" form of autosom
Fine mapping and genetic heterogeneity in the pure form of autosomal dominant familial spastic paraplegia
β Scribed by Allison Ashley-Koch; Erin R. Bonner; P. Craig Gaskell; Sandra G. West; Richard Tim; Chantelle M. Wolpert; Rodney Jones; Carolyn D. Farrell; Martha Nance; Ingrid K. Svenson; Douglas A. Marchuk; Rose-Mary N. Boustany; Jeffery M. Vance; William K. Scott; Margaret A. Pericak-Vance
- Book ID
- 106257393
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 83 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1364-6745
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Familial spastic paraplegia (FSP), characterized by progressive spasticity of the lower extremities, is in its "pure" form generally of autosomal dominant inheritance pattern. Hazan et al. "at Genet 5:163-167, 19931 reported tight linkage of a large FSP family to the highly polymorphic microsatellit
Hereditary spastic paraplegias (HSP) comprise a genetically and clinically heterogeneous group of neurodegenerative disorders characterised by progressive spasticity and hyperreflexia of the lower limbs. Autosomal dominant hereditary spastic paraplegia linked to the SPG3A locus on chromosome 14q11-2