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Fine Exon–Intron Structure of the Fanconi Anemia Group A (FAA) Gene and Characterization of Two Genomic Deletions

✍ Scribed by Marta Centra; Elena Memeo; Maria d'Apolito; Maria Savino; Leonarda Ianzano; Angelo Notarangelo; Jingmei Liu; Norman A Doggett; Leopoldo Zelante; Anna Savoia


Book ID
115614360
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
241 KB
Volume
51
Category
Article
ISSN
0888-7543

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Fanconi anemia (FA) is an autosomal recessive syndrome associated with hypersensitivity to DNA cross-linking agents and predisposition to neoplasia. Eight complementation groups (AH) have been described, but the only FA genes cloned so far are FAC and FAA. We have recently identified 40 different ge