𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Figures of merit for the determination of the polymorphic purity of carbamazepine by infrared spectroscopy and multivariate calibration

✍ Scribed by Jez Willian B. Braga; Ronei Jesus Poppi

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
143 KB
Volume
93
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

✦ Synopsis

Polymorphism is an important property in the quality control of pharmaceutical products. In this regard, partial least squares regression and the net analytical signal were used to build and validate a multivariate calibration model using diffuse reflectance infrared spectroscopy in the region of 900-1100 cm(-1) for the determination of the polymorphic purity of carbamazepine. Physical mixtures of the polymorphs were made by weight, from 80 to 100% (w/w) form III mixed with form I. Figures of merit, such as sensitivity, analytical sensitivity, selectivity, confidence limits, precision (mean, repeatability, intermediate), accuracy, and signal-to-noise ratio were calculated. Feasible results were obtained with maximum absolute error of 2% and an average error of 0.53%, indicating that the proposed methodology can be used by the pharmaceutical industry as an alternative to the X-ray diffraction (United States Pharmacopoeiamethod).

📜 SIMILAR VOLUMES

A multivariate calibration approach for
A multivariate calibration approach for determination of petroleum hydrocarbons in water by means of IR spectroscopy
✍ María Dolores Ruiz; Isneri Talavera Bustamante; Angel Dago; Noslen Hernández; An 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 124 KB 👁 1 views

## Abstract The goal of this paper is the development of a multivariate calibration method for the quantitative determination of petroleum hydrocarbons in water and waste water by using FT‐IR spectroscopy and PLS as a regression method to improve the results attained at the present time through the

Determination of the optical purity of s
Determination of the optical purity of some substituted N-phenylpropionamides by NMR spectroscopy
✍ Günther Snatzke; John E. Fox; Mustafa M. El-Abadelah 📂 Article 📅 1973 🏛 John Wiley and Sons 🌐 English ⚖ 478 KB

## Abstract The NMR spectra of a series of chiral propionamides have been determined in D(+)1‐phenylethylamine solution. The α‐methine protons of the propionic acid moiety in the propionamide enantiomers were found to be anisochronous in this solvent. The sense of non‐equivalence of these protons w