𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Determination of the optical purity of some substituted N-phenylpropionamides by NMR spectroscopy

✍ Scribed by Günther Snatzke; John E. Fox; Mustafa M. El-Abadelah

Publisher
John Wiley and Sons
Year
1973
Tongue
English
Weight
478 KB
Volume
5
Category
Article
ISSN
0749-1581

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The NMR spectra of a series of chiral propionamides have been determined in D(+)1‐phenylethylamine solution. The α‐methine protons of the propionic acid moiety in the propionamide enantiomers were found to be anisochronous in this solvent. The sense of non‐equivalence of these protons was found to be the same for all members of a homochiral series. The chemical shift difference between their signals was demonstrated to be dependent upon the temperature and concentration of the solution. A method is described whereby the enantiomeric purity of the amides could be calculated from these signals in cases where the position of the baseline in their spectra was unknown.

📜 SIMILAR VOLUMES

Determination of the enantiomeric purity
Determination of the enantiomeric purity of disubstituted β-lactams by NMR spectroscopy using a chiral shift reagent
✍ J. Belleney; C. Bui; F. J. Carriere 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 481 KB

## Abstract The enantiomeric purities of disubstituted β‐lactams were determined by ^1^H and ^13^C NMR spectroscopy using tris[3‐(trifluoromethylhydroxymethylene)‐d‐camphorato]europium(III), Eu(tfc)~3~, as a chiral shift reagent. Using a [Eu(tfc)~3~]/[lactam] ratio of 0.5, most of the resonances we

Determination of the configuration of su
Determination of the configuration of substituted 1,4:3,6-dianhydrohexitols by 13C NMR spectroscopy
✍ P. Sohár; G. Medgyes; J. Kuszmann 📂 Article 📅 1978 🏛 John Wiley and Sons 🌐 English ⚖ 241 KB

## Abstract The configurations of 1,4:3,6‐dianhydro‐2,5‐di‐__O__‐mesyl‐D‐mannitol, 1,4:3,6‐dianhydro‐2,5‐di‐__O__‐mesyl‐D‐glucitol, 1,4:3,6‐dianhydro‐2,5‐di‐__O__‐mesyl‐L‐iditol, 1,4:3:6‐dianhtydro‐2‐deoxy‐2‐iodo‐5‐__O__‐mesyl‐D‐mannitol, 1,4:3:6‐dianhtydro‐2‐deoxy‐2‐iodo‐5‐__O__‐mesyl‐D‐glucitol,

Determination of enantiomeric excess by
Determination of enantiomeric excess by 13C NMR spectroscopy
✍ V. N. Gogte; R. K. Nanda; A. A. Natu; V. S. Pandit; M. K. Sastry 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 English ⚖ 283 KB

Oxazolidine derivatives of p-amino alcohols such as ephedrine have been resolved by -C NMR spedroscopy using Eu(hfc), as a chiral shift reagent. The method is quantitative in the determination of enantiomeric excess, and is advantageous where 'H NMR is of limited use owing, for example, to signitica

Determination of optical purity and abso
Determination of optical purity and absolute configuration of natural 12-hydroxystearic acid by the 1H NMR anisotropy method
✍ Satoshi Murakami; Kazuhiro Satou; Taturo Kijima; Masataka Watanabe; Taeko Izumi 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 271 KB 👁 1 views

## Abstract The enantiopure of (__R__)‐(−) MαNPA was allowed to react with racemic 18‐(__tert__‐butyldimethylsilyloxy)‐5‐octadecayne‐7‐ol which was derived from dodecane‐1,12‐diol, yielding diastereomeric esters mixture. These racemic esters were easily separated by HPLC on silica‐gel. The absolute